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Chemical structure of SD 0006

GC19325

SD 0006

Also known as 1-[4-[3-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-5-yl]piperidin-1-yl]-2-hydroxyethanone

SD-06 is a p38 MAP kinase inhibitor; inhibits p38α with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats (83% inhibition at 1mg/kg, po)·IC50 value: 170 nM

ChemicalCAS271576-80-8MW397.86FormulaC20H20ClN5O2
CAS number
271576-80-8
Molecular weight
397.86
Formula
C20H20ClN5O2
Solubility
DMSO ： ≥ 29 mg/mL (72·89 mM)
InChIKey
CATQHDWESBRRQA-UHFFFAOYSA-N
Catalogue number
GC19325
Brand
GLPBIO
Computed properties PubChem CID 9865587 · XLogP 1.9 · TPSA 95 Ų · H-bond donors 2
XLogP
1.9
TPSA
95 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
28

SMILES C1CN(CCC1C2=C(C(=NN2)C3=CC=C(C=C3)Cl)C4=NC=NC=C4)C(=O)CO

Computed descriptors from PubChem (CID 9865587), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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