GC19290
PF-3084014
Also known as (2S)-2-[[(2S)-6,8-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl]amino]-N-[1-[1-(2,2-dimethylpropylamino)-2-methylpropan-2-yl]imidazol-4-yl]pentanamide
PF-3084014 (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6·2 nM· Inhibition of Notch signaling by PF-3084014 while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers
ChemicalCAS1290543-63-3MW489.64FormulaC27H41F2N5O
- CAS number
- 1290543-63-3
- Molecular weight
- 489.64
- Formula
- C27H41F2N5O
- Solubility
- DMSO ： ≥ 50 mg/mL (102·12 mM);Water ： ＜ 0·1 mg/mL (insoluble)
- InChIKey
- VFCRKLWBYMDAED-REWPJTCUSA-N
- Catalogue number
- GC19290
- Brand
- GLPBIO
Computed properties PubChem CID 46224413 · XLogP 4.8 · TPSA 71 Ų · H-bond donors 3
- XLogP
- 4.8
- TPSA
- 71 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Rotatable bonds
- 11
- Heavy atoms
- 35
SMILES CCC[C@@H](C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)N[C@H]2CCC3=C(C2)C(=CC(=C3)F)F
Computed descriptors from PubChem (CID 46224413), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il