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Chemical structure of PF06650833

GC19287

PF06650833

Also known as 1-[[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy]-7-methoxyisoquinoline-6-carboxamide

PF06650833 (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0·2 and 2·4 nM in the cell and PBMC assay, respectively

ChemicalCAS1817626-54-2MW361.37FormulaC18H20FN3O4
CAS number
1817626-54-2
Molecular weight
361.37
Formula
C18H20FN3O4
Solubility
DMSO ： ≥ 33 mg/mL (91·32 mM)
InChIKey
JKDGKIBAOAFRPJ-ZBINZKHDSA-N
Catalogue number
GC19287
Brand
GLPBIO
Computed properties PubChem CID 118414016 · XLogP 2 · TPSA 104 Ų · H-bond donors 2
XLogP
2
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
26

SMILES CC[C@H]1[C@H](NC(=O)[C@H]1F)COC2=NC=CC3=CC(=C(C=C32)OC)C(=O)N

Computed descriptors from PubChem (CID 118414016), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.