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Chemical structure of Genz-123346

GC19163

Genz-123346

Also known as bis(N-[(1R,2R)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-hydroxy-3-pyrrolidin-1-ylpropan-2-yl]nonanamide);(2R,3R)-2,3-dihydroxybutanedioic acid

Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; inhibits GM1 with IC50 value of 14 nM

ChemicalCAS943344-58-9MW987.23FormulaC52H82N4O14
CAS number
943344-58-9
Molecular weight
987.23
Formula
C52H82N4O14
Solubility
DMSO ： ≥ 100 mg/mL (238·91 mM)
InChIKey
ZRGZTIAIHNUMCZ-DQKXIDSGSA-N
Catalogue number
GC19163
Brand
GLPBIO
Computed properties PubChem CID 92044364 · TPSA 257 Ų · H-bond donors 8 · H-bond acceptors 16
TPSA
257 Ų
H-bond donors
8
H-bond acceptors
16
Rotatable bonds
27
Heavy atoms
70

SMILES CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@@H](C2=CC3=C(C=C2)OCCO3)O.CCCCCCCCC(=O)N[C@H](CN1CCCC1)[C@@H](C2=CC3=C(C=C2)OCCO3)O.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O

Computed descriptors from PubChem (CID 92044364), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.