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Chemical structure of Fevipiprant

GC19153

Fevipiprant

Also known as 2-[2-methyl-1-[[4-methylsulfonyl-2-(trifluoromethyl)phenyl]methyl]pyrrolo[2,3-b]pyridin-3-yl]acetic acid

Fevipiprant(QAW039) is a selective, potent, reversible competitive CRTh2 antagonist with an in vitro dissociation constant KD value of 1·1nM at the CRTh2 receptor and an IC50 value of 0·44 nM for inhibition of PGD2-induced eosinophil shape change in human whole blood

ChemicalCAS872365-14-5MW426.41FormulaC19H17F3N2O4S
CAS number
872365-14-5
Molecular weight
426.41
Formula
C19H17F3N2O4S
Solubility
DMSO ： ≥ 32 mg/mL (75·05 mM)
InChIKey
GFPPXZDRVCSVNR-UHFFFAOYSA-N
Catalogue number
GC19153
Brand
GLPBIO
Computed properties PubChem CID 23582412 · XLogP 2.8 · TPSA 97.6 Ų · H-bond donors 1
XLogP
2.8
TPSA
97.6 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
29

SMILES CC1=C(C2=C(N1CC3=C(C=C(C=C3)S(=O)(=O)C)C(F)(F)F)N=CC=C2)CC(=O)O

Computed descriptors from PubChem (CID 23582412), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Pricing
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Documents
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