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Chemical structure of CCT241736

GC19092

CCT241736

Also known as 6-chloro-7-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-2-(1,3-dimethylpyrazol-4-yl)-1H-imidazo[4,5-b]pyridine

CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor, which inhibits Aurora kinases (Aurora-A Kd, 7·5 nM, IC50, 38 nM; Aurora-B Kd, 48 nM), FLT3 kinase (Kd, 6·2 nM), and FLT3 mutants including FLT3-ITD (Kd, 38 nM) and FLT3(D835Y) (Kd, 14 nM)

ChemicalCAS1402709-93-6MW456.37FormulaC22H23Cl2N7
CAS number
1402709-93-6
Molecular weight
456.37
Formula
C22H23Cl2N7
Solubility
DMSO ： 75 mg/mL (164·34 mM);Water ： ＜ 0·1 mg/mL (insoluble)
InChIKey
AKJBLKUZXRMECW-UHFFFAOYSA-N
Catalogue number
GC19092
Brand
GLPBIO
Computed properties PubChem CID 71454279 · XLogP 3.8 · TPSA 65.9 Ų · H-bond donors 1
XLogP
3.8
TPSA
65.9 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
31

SMILES CC1=NN(C=C1C2=NC3=NC=C(C(=C3N2)N4CCN(CC4)CC5=CC=C(C=C5)Cl)Cl)C

Computed descriptors from PubChem (CID 71454279), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.