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Chemical structure of Avapritinib

GC19074

Avapritinib

Also known as (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine

Avapritinib is a potent and selective exon 17 mutant KIT kinase inhibitor with IC50 of 0·27 nM for KIT D816V

ChemicalCAS1703793-34-3MW498.56FormulaC26H27FN10
CAS number
1703793-34-3
Molecular weight
498.56
Formula
C26H27FN10
Solubility
DMSO ： ≥ 83·33 mg/mL (167·14 mM)
InChIKey
DWYRIWUZIJHQKQ-SANMLTNESA-N
Catalogue number
GC19074
Brand
GLPBIO
Computed properties PubChem CID 118023034 · XLogP 1.9 · TPSA 106 Ų · H-bond donors 1
XLogP
1.9
TPSA
106 Ų
H-bond donors
1
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
37

SMILES C[C@](C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N

Computed descriptors from PubChem (CID 118023034), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.