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Chemical structure of AF-353

GC19022

AF-353

Also known as 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8·0)

ChemicalCAS865305-30-2MW400.21FormulaC14H17IN4O2
CAS number
865305-30-2
Molecular weight
400.21
Formula
C14H17IN4O2
Solubility
DMSO ： ≥ 32 mg/mL (79·96 mM)
InChIKey
AATPYXMXFBBKFO-UHFFFAOYSA-N
Catalogue number
GC19022
Brand
GLPBIO
Computed properties PubChem CID 15953802 · XLogP 2.8 · TPSA 96.3 Ų · H-bond donors 2
XLogP
2.8
TPSA
96.3 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
21

SMILES CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC

Computed descriptors from PubChem (CID 15953802), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.