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Chemical structure of SKA-121

GC19004

SKA-121

Also known as 5-methylbenzo[g][1,3]benzoxazol-2-amine

SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3·1) with an EC50 value of 109 nM using whole-cell patch-clamp electrophysiology with calcium in the internal solution

ChemicalCAS1820708-73-3MW198.2FormulaC12H10N2O
CAS number
1820708-73-3
Molecular weight
198.2
Formula
C12H10N2O
Solubility
DMF： 50 mg/ml,DMSO： 50 mg/ml,DMSO：PBS (pH 7·2) (1：1)： 0·5 mg/ml,Ethanol： 10 mg/ml
InChIKey
JEGUERWMMMQFJV-UHFFFAOYSA-N
Catalogue number
GC19004
Brand
GLPBIO
Computed properties PubChem CID 91827362 · XLogP 3 · TPSA 52.1 Ų · H-bond donors 1
XLogP
3
TPSA
52.1 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
0
Heavy atoms
15

SMILES CC1=CC2=C(C3=CC=CC=C13)OC(=N2)N

Computed descriptors from PubChem (CID 91827362), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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