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Chemical structure of Pladienolide B

GC18780

Pladienolide B

Also known as [(2S,3S,4E,6S,7R,10R)-7,10-dihydroxy-2-[(2E,4E,6S)-7-[(2R,3R)-3-[(2R,3S)-3-hydroxypentan-2-yl]oxiran-2-yl]-6-methylhepta-2,4-dien-2-yl]-3,7-dimethyl-12-oxo-1-oxacyclododec-4-en-6-yl] acetate

Selectively bind splicing factor 3b and inhibits mRNA splicing

ChemicalCAS445493-23-2MW536.7FormulaC30H48O8
CAS number
445493-23-2
Molecular weight
536.7
Formula
C30H48O8
Solubility
DMF： Soluble,DMSO： Soluble,Ethanol： Soluble,Methanol： Soluble
InChIKey
SDOUORKJIJYJNW-QHOUZYGJSA-N
Catalogue number
GC18780
Brand
GLPBIO
Computed properties PubChem CID 16202130 · XLogP 4.2 · TPSA 126 Ų · H-bond donors 3
XLogP
4.2
TPSA
126 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
10
Heavy atoms
38

SMILES CC[C@@H]([C@@H](C)[C@@H]1[C@H](O1)C[C@H](C)/C=C/C=C(\C)/[C@@H]2[C@H](/C=C/[C@@H]([C@](CC[C@H](CC(=O)O2)O)(C)O)OC(=O)C)C)O

Computed descriptors from PubChem (CID 16202130), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.