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Chemical structure of NSC 617145

GC18507

NSC 617145

Also known as 3,4-dichloro-1-[3-(3,4-dichloro-2,5-dioxopyrrol-1-yl)-2,2-dimethylpropyl]pyrrole-2,5-dione

NSC 617145 is an inhibitor of WRN helicase (IC50 = 230 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner

ChemicalCAS203115-63-3MW400FormulaC13H10Cl4N2O4
CAS number
203115-63-3
Molecular weight
400
Formula
C13H10Cl4N2O4
Solubility
1mg/mL in DMSO, 2mg/mL in DMF
InChIKey
PCOXPBOKDABARQ-UHFFFAOYSA-N
Catalogue number
GC18507
Brand
GLPBIO
Computed properties PubChem CID 357621 · XLogP 3.3 · TPSA 74.8 Ų · H-bond donors 0
XLogP
3.3
TPSA
74.8 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
23

SMILES CC(C)(CN1C(=O)C(=C(C1=O)Cl)Cl)CN2C(=O)C(=C(C2=O)Cl)Cl

Computed descriptors from PubChem (CID 357621), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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