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Chemical structure of CGP 77675

GC18438

CGP 77675

Also known as 1-[2-[4-[4-amino-5-(3-methoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]piperidin-4-ol

CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively)

ChemicalCAS234772-64-6MW443.5FormulaC26H29N5O2
CAS number
234772-64-6
Molecular weight
443.5
Formula
C26H29N5O2
Solubility
DMSO: 10 mg/ml
InChIKey
WUPXZZWTHIZICK-UHFFFAOYSA-N
Catalogue number
GC18438
Brand
GLPBIO
Computed properties PubChem CID 5311381 · XLogP 3.7 · TPSA 89.4 Ų · H-bond donors 2
XLogP
3.7
TPSA
89.4 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
6
Heavy atoms
33

SMILES COC1=CC=CC(=C1)C2=CN(C3=NC=NC(=C23)N)C4=CC=C(C=C4)CCN5CCC(CC5)O

Computed descriptors from PubChem (CID 5311381), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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