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Chemical structure of Aloisine RP106

GC18386

Aloisine RP106

Also known as 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine

Aloisine is an inhibitor of Cdk1/cyclin B, Cdk5/p25, and GSK3 (IC50s = 0·70, 1·5, and 0·92 uM, respectively)

ChemicalCAS496864-15-4MW281.4FormulaC17H19N3O
CAS number
496864-15-4
Molecular weight
281.4
Formula
C17H19N3O
Solubility
DMF: 25 mg/ml,DMF:PBS (pH 7·2) (1:4): 0·2 mg/ml,DMSO: 12 mg/ml
InChIKey
WVMANZPBOBRWCB-UHFFFAOYSA-N
Catalogue number
GC18386
Brand
GLPBIO
Computed properties PubChem CID 3641059 · XLogP 3.8 · TPSA 50.8 Ų · H-bond donors 1
XLogP
3.8
TPSA
50.8 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
5
Heavy atoms
21

SMILES CCCCC1=C(NC2=NC=CN=C12)C3=CC=C(C=C3)OC

Computed descriptors from PubChem (CID 3641059), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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