Loading...
Chemical structure of Cilofexor

GC18212

Cilofexor

Also known as 2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid

Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = ＜25 nM in a FRET activity assay)

ChemicalCAS1418274-28-8MW586.9FormulaC28H22Cl3N3O5
CAS number
1418274-28-8
Molecular weight
586.9
Formula
C28H22Cl3N3O5
Solubility
DMF： 30 mg/ml,DMF：PBS (pH 7·2) (1：5)： 0·16 mg/ml,DMSO： 15 mg/ml
InChIKey
KZSKGLFYQAYZCO-UHFFFAOYSA-N
Catalogue number
GC18212
Brand
GLPBIO
Computed properties PubChem CID 71228883 · XLogP 5.3 · TPSA 109 Ų · H-bond donors 2
XLogP
5.3
TPSA
109 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
39

SMILES C1CC1C2=C(C(=NO2)C3=C(C=CC=C3Cl)Cl)COC4=CC(=C(C=C4)C5(CN(C5)C6=NC=CC(=C6)C(=O)O)O)Cl

Computed descriptors from PubChem (CID 71228883), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.