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Chemical structure of Linifanib

GC17958

Linifanib

Also listed as Linifanib (ABT-869)

Linifanib (ABT-869) (ABT-869) is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family with IC50s of 4, 3, 66, and 4 nM for KDR, FLT1, PDGFRβ, and FLT3, respectively· Linifanib (ABT-869) shows prominent antitumor activity· Linifanib (ABT-869) has much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases· Linifanib (ABT-869) is a specific miR-10b inhibitor that blocks miR-10b biogenesis

ChemicalCAS796967-16-3MW375.41FormulaC21H18FN5O
CAS number
796967-16-3
Molecular weight
375.41
Formula
C21H18FN5O
Solubility
≥ 18·75mg/mL in DMSO
InChIKey
MPVGZUGXCQEXTM-UHFFFAOYSA-N
Catalogue number
GC17958
Brand
GLPBIO
Computed properties PubChem CID 11485656 · XLogP 3.9 · TPSA 95.8 Ų · H-bond donors 4
XLogP
3.9
TPSA
95.8 Ų
H-bond donors
4
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
28

SMILES CC1=CC(=C(C=C1)F)NC(=O)NC2=CC=C(C=C2)C3=C4C(=CC=C3)NN=C4N

Computed descriptors from PubChem (CID 11485656), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.