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Chemical structure of Naftopidil DiHCl

GC17765

Naftopidil DiHCl

Also known as 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;dihydrochloride

Naftopidil DiHCl (KT-611 dihydrochloride) is a selective alpha1-adrenoceptor antagonist, with Kis of 3·7 nM, 20 nM and 1·2 nM for the cloned human α1a-, α1b- and α1d-adrenoceptor subtypes, respectively· Naftopidil DiHCl has antiproliferative effects· Naftopidil DiHCl can be used for the research of prostate hyperplasia

ChemicalCAS57149-08-3MW465.41FormulaC24H28N2O3·2HCl
CAS number
57149-08-3
Molecular weight
465.41
Formula
C24H28N2O3·2HCl
Solubility
DMSO : 41mg/mL
InChIKey
HZVCEQMJXMUXJF-UHFFFAOYSA-N
Catalogue number
GC17765
Brand
GLPBIO
Computed properties PubChem CID 11957660 · TPSA 45.2 Ų · H-bond donors 3 · H-bond acceptors 5
TPSA
45.2 Ų
H-bond donors
3
H-bond acceptors
5
Rotatable bonds
7
Heavy atoms
31

SMILES COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O.Cl.Cl

Computed descriptors from PubChem (CID 11957660), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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