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Chemical structure of Kifunensine

GC17735

Kifunensine

Also known as (5R,6R,7S,8R,8aS)-6,7,8-trihydroxy-5-(hydroxymethyl)-1,5,6,7,8,8a-hexahydroimidazo[1,2-a]pyridine-2,3-dione

Kifunensine (FR900494) is a potent mannosidase I inhibitor that effectively inhibits the activities of endoplasmic reticulum α-1,2-mannosidase I (MAN1B1) and class I mannosidase Golgi subfamily (Golgi α-mannosidase IA, IB, and IC) with Ki values of 130 and 23 nM, respectively· Kifunensine also inhibits mung bean α-1,2-mannosidase I with IC50 values of 20-50 nM

ChemicalCAS109944-15-2MW232.19FormulaC8H12N2O6
CAS number
109944-15-2
Molecular weight
232.19
Formula
C8H12N2O6
Solubility
DMSO ： 11·9 mg/mL (51·25 mM; Need ultrasonic);0·5mg/mL in warm distilled water
InChIKey
OIURYJWYVIAOCW-PQMKYFCFSA-N
Catalogue number
GC17735
Brand
GLPBIO
Computed properties PubChem CID 130611 · XLogP -2.8 · TPSA 130 Ų · H-bond donors 5
XLogP
-2.8
TPSA
130 Ų
H-bond donors
5
H-bond acceptors
6
Rotatable bonds
1
Heavy atoms
16

SMILES C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H]2N1C(=O)C(=O)N2)O)O)O)O

Computed descriptors from PubChem (CID 130611), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.