Loading...
Chemical structure of R428

GC17618

R428

Also known as 1-(3,4-diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine

R428, as a Axl inhibitor, blocks Axl autophosphorylation on its C-terminal docking site, Tyr821, at nanomolar concentrations[1]

ChemicalCAS1037624-75-1MW506.64FormulaC30H34N8
CAS number
1037624-75-1
Molecular weight
506.64
Formula
C30H34N8
Solubility
≥ 25mg/mL in DMSO with gentle warming
InChIKey
KXMZDGSRSGHMMK-VWLOTQADSA-N
Catalogue number
GC17618
Brand
GLPBIO
Computed properties PubChem CID 46215462 · XLogP 5.5 · TPSA 97.8 Ų · H-bond donors 2
XLogP
5.5
TPSA
97.8 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
38

SMILES C1CCN(C1)[C@H]2CCC3=C(CC2)C=C(C=C3)NC4=NN(C(=N4)N)C5=NN=C6C(=C5)CCCC7=CC=CC=C76

Computed descriptors from PubChem (CID 46215462), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.