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Chemical structure of Quizartinib

GC17615

Quizartinib

Also listed as Quizartinib (AC220)

Quizartinib (AC220) (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1·6 nM· Quizartinib (AC220) inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4·2 and 1·1 nM, respectively· Quizartinib (AC220) can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader· Quizartinib (AC220) induces apoptosis

ChemicalCAS950769-58-1MW560.67FormulaC29H32N6O4S
CAS number
950769-58-1
Molecular weight
560.67
Formula
C29H32N6O4S
Solubility
≥ 28·0335mg/mL in DMSO
InChIKey
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Catalogue number
GC17615
Brand
GLPBIO
Computed properties PubChem CID 24889392 · XLogP 5.6 · TPSA 134 Ų · H-bond donors 2
XLogP
5.6
TPSA
134 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
40

SMILES CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3

Computed descriptors from PubChem (CID 24889392), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.