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Chemical structure of CHIR-99021 (CT99021) HCl

GC17153

CHIR-99021 (CT99021) HCl

Also known as 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile;hydrochloride

Laduviglusib (CHIR-99021) monohydrochloride is a potent and selective GSK-3α/β inhibitor with IC50s of 10 nM and 6·7 nM· CHIR-99021 (CT99021) HCl shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases· CHIR-99021 (CT99021) HCl is also a potent Wnt/β-catenin signaling pathway activator· CHIR-99021 (CT99021) HCl enhances mouse and human embryonic stem cells self-renewal· CHIR-99021 (CT99021) HCl induces autophagy

ChemicalCAS1797989-42-4MW501.8FormulaC22H18Cl2N8·HCl
CAS number
1797989-42-4
Molecular weight
501.8
Formula
C22H18Cl2N8·HCl
Solubility
≥ 25·1mg/mL in DMSO
InChIKey
SCQDMKUZHIGAIB-UHFFFAOYSA-N
Catalogue number
GC17153
Brand
GLPBIO
Computed properties PubChem CID 71295844 · TPSA 115 Ų · H-bond donors 4 · H-bond acceptors 7
TPSA
115 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
33

SMILES CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl

Computed descriptors from PubChem (CID 71295844), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.