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Chemical structure of ICG 001

GC16893

ICG 001

Also known as (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide

ICG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway· It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 μM [1]

ChemicalCAS780757-88-2MW548.63FormulaC33H32N4O4
CAS number
780757-88-2
Molecular weight
548.63
Formula
C33H32N4O4
Solubility
≥ 27·4315mg/mL in DMSO, ≥ 35·47 mg/mL in EtOH with ultrasonic
InChIKey
HQWTUOLCGKIECB-XZWHSSHBSA-N
Catalogue number
GC16893
Brand
GLPBIO
Computed properties PubChem CID 11238147 · XLogP 4.1 · TPSA 93.2 Ų · H-bond donors 2
XLogP
4.1
TPSA
93.2 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
6
Heavy atoms
41

SMILES C1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6

Computed descriptors from PubChem (CID 11238147), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.