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Chemical structure of LDN-211904

GC16798

LDN-211904

Also known as N-(2-chlorophenyl)-6-piperidin-4-ylimidazo[1,2-a]pyridine-3-carboxamide;oxalic acid

LDN-211904 (compound 32) is a potent and selective EphB3 inhibitor with an IC50 of 0·079 μM· LDN-211904 shows good metabolic stability in mouse liver microsomes· LDN-211904 with cetuximab could be effective in inhibiting STAT3-activated CSC stemness and cetuximab resistance in CRC

ChemicalCAS1198408-78-4MW444.9FormulaC19H19ClN4O • C2H2O4
CAS number
1198408-78-4
Molecular weight
444.9
Formula
C19H19ClN4O • C2H2O4
Solubility
≤20mg/ml in DMSO;0·5mg/ml in dimethyl formamide
InChIKey
ODBJGLKPAQMCJA-UHFFFAOYSA-N
Catalogue number
GC16798
Brand
GLPBIO
Computed properties PubChem CID 46882744 · TPSA 133 Ų · H-bond donors 4 · H-bond acceptors 7
TPSA
133 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
31

SMILES C1CNCCC1C2=CN3C(=NC=C3C(=O)NC4=CC=CC=C4Cl)C=C2.C(=O)(C(=O)O)O

Computed descriptors from PubChem (CID 46882744), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.