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Chemical structure of RepSox

GC16793

RepSox

Also known as 2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine

RepSox is a potent and selective inhibitor of transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5) with an IC50 of 23nM· RepSox inhibits ALK5 autophosphorylation with an IC50 of 4nM

ChemicalCAS446859-33-2MW287.32FormulaC17H13N5
CAS number
446859-33-2
Molecular weight
287.32
Formula
C17H13N5
Solubility
≥ 14·35 mg/mL in DMSO, ≥ 47·9 mg/mL in EtOH with gentle warming
InChIKey
LBPKYPYHDKKRFS-UHFFFAOYSA-N
Catalogue number
GC16793
Brand
GLPBIO
Computed properties PubChem CID 449054 · XLogP 2.2 · TPSA 67.4 Ų · H-bond donors 1
XLogP
2.2
TPSA
67.4 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
22

SMILES CC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

Computed descriptors from PubChem (CID 449054), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.