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Chemical structure of EGF816

GC16321

EGF816

Also known as N-[7-chloro-1-[(3R)-1-[(E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]benzimidazol-2-yl]-2-methylpyridine-4-carboxamide

EGF816 (EGF816) is a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0·222 min-1 on EGFR(L858R/790M) mutant, respectively

ChemicalCAS1508250-71-2MW495.02FormulaC26H31ClN6O2
CAS number
1508250-71-2
Molecular weight
495.02
Formula
C26H31ClN6O2
Solubility
DMF： 33 mg/ml,DMSO： 33 mg/ml,Ethanol： 33 mg/ml,Ethanol：PBS (pH 7·2) (1：4)： 0·20 mg/ml
InChIKey
IOMMMLWIABWRKL-WUTDNEBXSA-N
Catalogue number
GC16321
Brand
GLPBIO
Computed properties PubChem CID 72703790 · XLogP 3.2 · TPSA 83.4 Ų · H-bond donors 1
XLogP
3.2
TPSA
83.4 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
6
Heavy atoms
35

SMILES CC1=NC=CC(=C1)C(=O)NC2=NC3=C(N2[C@@H]4CCCCN(C4)C(=O)/C=C/CN(C)C)C(=CC=C3)Cl

Computed descriptors from PubChem (CID 72703790), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.