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Chemical structure of AZD-9291

GC16308

AZD-9291

Also known as N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide

AZD-9291 (AZD9291) is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M, respectively· AZD-9291 overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer

ChemicalCAS1421373-65-0MW499.61FormulaC28H33N7O2
CAS number
1421373-65-0
Molecular weight
499.61
Formula
C28H33N7O2
Solubility
≥ 24·98mg/mL in DMSO
InChIKey
DUYJMQONPNNFPI-UHFFFAOYSA-N
Catalogue number
GC16308
Brand
GLPBIO
Computed properties PubChem CID 71496458 · XLogP 3.7 · TPSA 87.6 Ų · H-bond donors 2
XLogP
3.7
TPSA
87.6 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
37

SMILES CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

Computed descriptors from PubChem (CID 71496458), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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