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Chemical structure of Glasdegib

GC16230

Glasdegib

Also listed as PF-04449913

PF-04449913 (PF-04449913) is a potent and orally bioavailable smoothened inhibitor· PF-04449913 (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM

ChemicalCAS1095173-27-5MW374.44FormulaC21H22N6O
CAS number
1095173-27-5
Molecular weight
374.44
Formula
C21H22N6O
Solubility
≥ 20·15mg/mL in DMSO
InChIKey
SFNSLLSYNZWZQG-VQIMIIECSA-N
Catalogue number
GC16230
Brand
GLPBIO
Computed properties PubChem CID 25166913 · XLogP 2.4 · TPSA 96.8 Ų · H-bond donors 3
XLogP
2.4
TPSA
96.8 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
28

SMILES CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N

Computed descriptors from PubChem (CID 25166913), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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