GC15588
PHA-848125
Also known as N,1,4,4-tetramethyl-8-[4-(4-methylpiperazin-1-yl)anilino]-5H-pyrazolo[4,5-h]quinazoline-3-carboxamide
PHA-848125 (PHA-848125) is a potent, ATP-competitive and dual inhibitor of CDK and Tropomyosin receptor kinase (TRK), with IC50s of 45, 150, 160, 363, 398 nM and 53 nM for cyclin A/CDK2, cyclin H/CDK7, cyclin D1/CDK4, cyclin E/CDK2, cyclin B/CDK1 and TRKA, respectively
ChemicalCAS802539-81-7MW460.57FormulaC25H32N8O
- CAS number
- 802539-81-7
- Molecular weight
- 460.57
- Formula
- C25H32N8O
- Solubility
- ≥ 23·05mg/mL in DMSO
- InChIKey
- RXZMYLDMFYNEIM-UHFFFAOYSA-N
- Catalogue number
- GC15588
- Brand
- GLPBIO
Computed properties PubChem CID 16718576 · XLogP 2.8 · TPSA 91.2 Ų · H-bond donors 2
- XLogP
- 2.8
- TPSA
- 91.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Rotatable bonds
- 4
- Heavy atoms
- 34
SMILES CC1(CC2=CN=C(N=C2C3=C1C(=NN3C)C(=O)NC)NC4=CC=C(C=C4)N5CCN(CC5)C)C
Computed descriptors from PubChem (CID 16718576), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il