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Chemical structure of HOE 140

GC15587

HOE 140

Also known as (2S)-2-[[(3aS,7aS)-1-[2-[(2S)-2-[[(2S)-2-[[2-[[(4R)-1-[1-[2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid

HOE 140 (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC50 and Ki of 1·07 nM and 0·798 nM respectively

ChemicalCAS130308-48-4MW1304.52FormulaC59H89N19O13S
CAS number
130308-48-4
Molecular weight
1304.52
Formula
C59H89N19O13S
Solubility
Soluble to 1 mg/ml in sterile water
InChIKey
QURWXBZNHXJZBE-MCDGZUPGSA-N
Catalogue number
GC15587
Brand
GLPBIO
Computed properties PubChem CID 71364 · XLogP -6.4 · TPSA 552 Ų · H-bond donors 15
XLogP
-6.4
TPSA
552 Ų
H-bond donors
15
H-bond acceptors
18
Rotatable bonds
30
Heavy atoms
92

SMILES C1CC[C@H]2[C@@H](C1)CC(N2C(=O)C3CC4=CC=CC=C4CN3C(=O)[C@H](CO)NC(=O)[C@H](CC5=CC=CS5)NC(=O)CNC(=O)C6C[C@H](CN6C(=O)C7CCCN7C(=O)C(CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)N)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O

Computed descriptors from PubChem (CID 71364), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.