Loading...
Chemical structure of ACP-196

GC15453

ACP-196

Also known as 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide

ACP-196 (ACP-196) is an orally active, irreversible, and highly selective second-generation BTK inhibitor· ACP-196 binds covalently to Cys481 in the ATP-binding pocket of BTK· ACP-196 demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL)

ChemicalCAS1420477-60-6MW465.51FormulaC26H23N7O2
CAS number
1420477-60-6
Molecular weight
465.51
Formula
C26H23N7O2
Solubility
≥ 46·6mg/mL in DMSO with gentle warming
InChIKey
WDENQIQQYWYTPO-IBGZPJMESA-N
Catalogue number
GC15453
Brand
GLPBIO
Computed properties PubChem CID 71226662 · XLogP 3 · TPSA 119 Ų · H-bond donors 2
XLogP
3
TPSA
119 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
35

SMILES CC#CC(=O)N1CCC[C@H]1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5

Computed descriptors from PubChem (CID 71226662), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.