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Chemical structure of U 18666A

GC15284

U 18666A

Also known as (3S,8R,9S,10R,13S,14S)-3-[2-(diethylamino)ethoxy]-10,13-dimethyl-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one;hydrochloride

U18666A is a small molecule with cellular permeability and amphiphilism that inhibits 3β-hydroxysterol-Δ (24)-reductase (DHCR24) activity, thereby preventing cholesterol outflow from late endosomes and lysosomes

ChemicalCAS3039-71-2MW424.07FormulaC25H41NO2·HCl
CAS number
3039-71-2
Molecular weight
424.07
Formula
C25H41NO2·HCl
Solubility
20mg/mL in ethanol, 10mg/mL in DMSO or DMF
InChIKey
GZFYZYBWLCYBMI-MYZJJQSMSA-N
Catalogue number
GC15284
Brand
GLPBIO
Computed properties PubChem CID 9954082 · TPSA 29.5 Ų · H-bond donors 1 · H-bond acceptors 3
TPSA
29.5 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
6
Heavy atoms
29

SMILES CCN(CC)CCO[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CCC4=O)C)C.Cl

Computed descriptors from PubChem (CID 9954082), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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