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Chemical structure of SR 8278

GC15275

SR 8278

Also known as ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate

SR 8278 is an antagonist of the nuclear receptor REV-ERBα that can inhibit the transcription of REV-ERBα with an EC50 value of 0·47μM

ChemicalCAS1254944-66-5MW361.48FormulaC18H19NO3S2
CAS number
1254944-66-5
Molecular weight
361.48
Formula
C18H19NO3S2
Solubility
≤15mg/ml in ethanol;≤10mg/ml in DMSO
InChIKey
UIEBLUZPSFAFOC-UHFFFAOYSA-N
Catalogue number
GC15275
Brand
GLPBIO
Computed properties PubChem CID 53393127 · XLogP 4.1 · TPSA 100 Ų · H-bond donors 0
XLogP
4.1
TPSA
100 Ų
H-bond donors
0
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
24

SMILES CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC

Computed descriptors from PubChem (CID 53393127), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.