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Chemical structure of Dabrafenib

GC15187

Dabrafenib

Also listed as Dabrafenib (GSK2118436)

Dabrafenib (GSK2118436) (GSK2118436A) is an ATP-competitive inhibitor of Raf with IC50s of 5 nM and 0·6 nM for C-Raf and B-RafV600E, respectively

ChemicalCAS1195765-45-7MW519.56FormulaC23H20F3N5O2S2
CAS number
1195765-45-7
Molecular weight
519.56
Formula
C23H20F3N5O2S2
Solubility
≥ 26mg/mL in DMSO, ≥ 2·59 mg/mL in EtOH with ultrasonic and warming
InChIKey
BFSMGDJOXZAERB-UHFFFAOYSA-N
Catalogue number
GC15187
Brand
GLPBIO
Computed properties PubChem CID 44462760 · XLogP 4.8 · TPSA 147 Ų · H-bond donors 2
XLogP
4.8
TPSA
147 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
6
Heavy atoms
35

SMILES CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

Computed descriptors from PubChem (CID 44462760), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.