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Chemical structure of Celastrol

GC15083

Celastrol

Also known as (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid

Celastrol is a proteasome inhibitor with a potent and preferred inhibition of purified 20S proteasome with an IC50 of 2·5 μM

ChemicalCAS34157-83-0MW450.61FormulaC29H38O4
CAS number
34157-83-0
Molecular weight
450.61
Formula
C29H38O4
Solubility
≥ 22·55mg/mL in DMSO
InChIKey
KQJSQWZMSAGSHN-JJWQIEBTSA-N
Catalogue number
GC15083
Brand
GLPBIO
Computed properties PubChem CID 122724 · XLogP 5.9 · TPSA 74.6 Ų · H-bond donors 2
XLogP
5.9
TPSA
74.6 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
1
Heavy atoms
33

SMILES CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O

Computed descriptors from PubChem (CID 122724), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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