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Chemical structure of SBE 13 HCl

GC14644

SBE 13 HCl

Also known as N-[[4-[(6-chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride

SBE 13 HCl is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE 13 HCl poorly inhibits Plk2 (IC50>66μM) or Plk3 (IC50=875nM)

ChemicalCAS1052532-15-6MW479.4FormulaC24H28Cl2N2O4
CAS number
1052532-15-6
Molecular weight
479.4
Formula
C24H28Cl2N2O4
Solubility
DMF： 10 mg/ml,DMF：PBS (pH 7·2) (1：5)： 0·16 mg/ml,DMSO： 1 mg/ml
InChIKey
QBGSVDJLQQXEGG-UHFFFAOYSA-N
Catalogue number
GC14644
Brand
GLPBIO
Computed properties PubChem CID 11948807 · TPSA 61.8 Ų · H-bond donors 2 · H-bond acceptors 6
TPSA
61.8 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
11
Heavy atoms
32

SMILES COC1=C(C=C(C=C1)CCNCC2=CC(=C(C=C2)OCC3=CN=C(C=C3)Cl)OC)OC.Cl

Computed descriptors from PubChem (CID 11948807), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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