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Chemical structure of Nilotinib

GC14129

Nilotinib

Also listed as Nilotinib(AMN-107)

Nilotinib(AMN-107) is a selective oral tyrosine kinase inhibitor that inhibits the autophosphorylation of native Bcr-Abl (WT p210) and mutant Bcr-Abl (E281K, E292K, F317L, M351T, and F486S) with IC50 values of 20, 42, 31, 38, 29, and 41nM, respectively

ChemicalCAS641571-10-0MW529.53FormulaC28H22F3N7O
CAS number
641571-10-0
Molecular weight
529.53
Formula
C28H22F3N7O
Solubility
≥ 26·5mg/mL in DMSO, ≥ 5mg/mL in EtOH with ultrasonic and warming
InChIKey
HHZIURLSWUIHRB-UHFFFAOYSA-N
Catalogue number
GC14129
Brand
GLPBIO
Computed properties PubChem CID 644241 · XLogP 4.9 · TPSA 97.6 Ų · H-bond donors 2
XLogP
4.9
TPSA
97.6 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
6
Heavy atoms
39

SMILES CC1=C(C=C(C=C1)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)N3C=C(N=C3)C)NC4=NC=CC(=N4)C5=CN=CC=C5

Computed descriptors from PubChem (CID 644241), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.