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Chemical structure of E-64

GC13418

E-64

Also known as (2S,3S)-3-[[(2S)-1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid

E-64 is a potent and irreversible inhibitor of cysteine proteases with an IC50 of 9nM for papain

ChemicalCAS66701-25-5MW357.41FormulaC15H27N5O5
CAS number
66701-25-5
Molecular weight
357.41
Formula
C15H27N5O5
Solubility
≥ 53·6mg/mL in DMSO
InChIKey
LTLYEAJONXGNFG-DCAQKATOSA-N
Catalogue number
GC13418
Brand
GLPBIO
Computed properties PubChem CID 123985 · XLogP -0.9 · TPSA 172 Ų · H-bond donors 5
XLogP
-0.9
TPSA
172 Ų
H-bond donors
5
H-bond acceptors
6
Rotatable bonds
11
Heavy atoms
25

SMILES CC(C)C[C@@H](C(=O)NCCCCN=C(N)N)NC(=O)[C@@H]1[C@H](O1)C(=O)O

Computed descriptors from PubChem (CID 123985), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.