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Chemical structure of AC480 (BMS-599626)

GC13257

AC480 (BMS-599626)

AC480 (BMS-599626) (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively· AC480 (BMS-599626) displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK· AC480 (BMS-599626) inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy

ChemicalCAS714971-09-2MW567.01FormulaC27H27FN8O3·HCl
CAS number
714971-09-2
Molecular weight
567.01
Formula
C27H27FN8O3·HCl
Solubility
≥ 28·35mg/mL in DMSO
Catalogue number
GC13257
Brand
GLPBIO

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.