Loading...
Chemical structure of Siramesine

GC13083

Siramesine

Also known as 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[1H-2-benzofuran-3,4'-piperidine]

Siramesine (Lu 28-179) is a potent sigma-2 receptor agonist· Siramesine has a subnanomolar affinity for sigma-2 receptors (IC50=0·12nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17nM)· Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes· Anti-cancer activity

ChemicalCAS147817-50-3MW454.58FormulaC30H31FN2O
CAS number
147817-50-3
Molecular weight
454.58
Formula
C30H31FN2O
Solubility
Soluble in DMSO
InChIKey
XWAONOGAGZNUSF-UHFFFAOYSA-N
Catalogue number
GC13083
Brand
GLPBIO
Computed properties PubChem CID 9829526 · XLogP 6 · TPSA 17.4 Ų · H-bond donors 0
XLogP
6
TPSA
17.4 Ų
H-bond donors
0
H-bond acceptors
3
Rotatable bonds
6
Heavy atoms
34

SMILES C1CN(CCC12C3=CC=CC=C3CO2)CCCCC4=CN(C5=CC=CC=C54)C6=CC=C(C=C6)F

Computed descriptors from PubChem (CID 9829526), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.