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Chemical structure of ML-291

GC13034

ML-291

Also known as N-[4-(4-chloropiperidin-1-yl)sulfonylphenyl]-5-nitrofuran-2-carboxamide

ML-291 is a UPR (unfolded protein response)-inducing sulfonamidebenzamide· ML-291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models· ML-291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden

ChemicalCAS1523437-16-2MW413.8FormulaC16H16ClN3O6S
CAS number
1523437-16-2
Molecular weight
413.8
Formula
C16H16ClN3O6S
Solubility
≤1mg/ml in DMSO;10mg/ml in dimethyl formamide
InChIKey
XKMLYHZJKCRLOI-UHFFFAOYSA-N
Catalogue number
GC13034
Brand
GLPBIO
Computed properties PubChem CID 52940465 · XLogP 2.6 · TPSA 134 Ų · H-bond donors 1
XLogP
2.6
TPSA
134 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
4
Heavy atoms
27

SMILES C1CN(CCC1Cl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=CC=C(O3)[N+](=O)[O-]

Computed descriptors from PubChem (CID 52940465), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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