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Chemical structure of Dapt

GC12942

Dapt

Also listed as DAPT (GSI-IX)

DAPT (GSI-IX) is an orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42 produced in human primary neuronal cultures, respectively

ChemicalCAS208255-80-5MW432.46FormulaC23H26F2N2O4
CAS number
208255-80-5
Molecular weight
432.46
Formula
C23H26F2N2O4
Solubility
≥ 21·623mg/mL in DMSO, ≥ 16·36 mg/mL in EtOH with ultrasonic
InChIKey
DWJXYEABWRJFSP-XOBRGWDASA-N
Catalogue number
GC12942
Brand
GLPBIO
Computed properties PubChem CID 5311272 · XLogP 3.7 · TPSA 84.5 Ų · H-bond donors 2
XLogP
3.7
TPSA
84.5 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
31

SMILES C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Computed descriptors from PubChem (CID 5311272), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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