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Chemical structure of Epoxomicin

GC12494

Epoxomicin

Also known as (2S,3S)-2-[[(2S,3S)-2-[acetyl(methyl)amino]-3-methylpentanoyl]amino]-N-[(2S,3R)-3-hydroxy-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-3-methylpentanamide

Epoxomicin is a selective proteasome inhibitor that effectively inhibits the chymotrypsin-like (CH-L) activity of the 20S proteasome, with an IC50 of approximately 40-80nM

ChemicalCAS134381-21-8MW554.7FormulaC28H50N4O7
CAS number
134381-21-8
Molecular weight
554.7
Formula
C28H50N4O7
Solubility
≥ 27·74mg/mL in DMSO
InChIKey
DOGIDQKFVLKMLQ-JTHVHQAWSA-N
Catalogue number
GC12494
Brand
GLPBIO
Computed properties PubChem CID 11226684 · XLogP 2.3 · TPSA 157 Ų · H-bond donors 4
XLogP
2.3
TPSA
157 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
16
Heavy atoms
39

SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(CO1)C)NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)C

Computed descriptors from PubChem (CID 11226684), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.