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Chemical structure of Pexmetinib

GC11857

Pexmetinib

Also listed as Pexmetinib (ARRY-614)

Pexmetinib (ARRY-614) is a potent Tie-2 and p38 MAPK dual inhibitor, with IC50s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia

ChemicalCAS945614-12-0MW556.63FormulaC31H33FN6O3
CAS number
945614-12-0
Molecular weight
556.63
Formula
C31H33FN6O3
Solubility
≥ 107·6 mg/mL in DMSO, ≥ 113 mg/mL in EtOH
InChIKey
LNMRSSIMGCDUTP-UHFFFAOYSA-N
Catalogue number
GC11857
Brand
GLPBIO
Computed properties PubChem CID 24765037 · XLogP 5.3 · TPSA 106 Ų · H-bond donors 3
XLogP
5.3
TPSA
106 Ų
H-bond donors
3
H-bond acceptors
6
Rotatable bonds
9
Heavy atoms
41

SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO

Computed descriptors from PubChem (CID 24765037), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.