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Chemical structure of CFM 4

GC11710

CFM 4

Also known as 1'-[(2-chlorophenyl)methyl]-5-phenylspiro[3H-1,3,4-thiadiazole-2,3'-indole]-2'-one

CFM 4 is a potent small molecular antagonist of CARP-1/APC-2 binding· CFM 4 prevents CARP-1 binding with APC-2, causes G2M cell cycle arrest, and induces apoptosis with an IC50 range of 10-15 μM· CFM 4 also suppresses growth of drug-resistant human breast cancer cells

ChemicalCAS331458-02-7MW405.9FormulaC22H16ClN3OS
CAS number
331458-02-7
Molecular weight
405.9
Formula
C22H16ClN3OS
Solubility
＜8·12mg/ml in DMSO
InChIKey
PMADITKBVODKSF-UHFFFAOYSA-N
Catalogue number
GC11710
Brand
GLPBIO
Computed properties PubChem CID 2871439 · XLogP 5.4 · TPSA 70 Ų · H-bond donors 1
XLogP
5.4
TPSA
70 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
28

SMILES C1=CC=C(C=C1)C2=NNC3(S2)C4=CC=CC=C4N(C3=O)CC5=CC=CC=C5Cl

Computed descriptors from PubChem (CID 2871439), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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