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Chemical structure of Cdk4/6 Inhibitor IV

GC11564

Cdk4/6 Inhibitor IV

Also known as 4-[[2-[(1-benzylindol-5-yl)amino]-6-(ethylamino)pyrimidin-4-yl]amino]cyclohexan-1-ol

GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6· GP-82996 has IC50s of 1·5, 5·6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively· GP-82996 induces the apoptosis of cancer cells U2OS· GP-82996 can be used in the research of cancer

ChemicalCAS359886-84-3MW456.6FormulaC27H32N6O
CAS number
359886-84-3
Molecular weight
456.6
Formula
C27H32N6O
Solubility
≤1mg/ml in ethanol;30mg/ml in DMSO;20mg/ml in dimethyl formamide
InChIKey
YVXCDLCJCIDFHE-UHFFFAOYSA-N
Catalogue number
GC11564
Brand
GLPBIO
Computed properties PubChem CID 24825971 · XLogP 5.4 · TPSA 87 Ų · H-bond donors 4
XLogP
5.4
TPSA
87 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
8
Heavy atoms
34

SMILES CCNC1=CC(=NC(=N1)NC2=CC3=C(C=C2)N(C=C3)CC4=CC=CC=C4)NC5CCC(CC5)O

Computed descriptors from PubChem (CID 24825971), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.