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Chemical structure of SB 431542

GC11545

SB 431542

Also known as 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide

SB-431542, a small molecule inhibitor of the type I TGF-β receptor, blocks intracellular mediators of TGF-1 signaling, which leads to decreased TGF-β1-mediated proliferation, cytokines and collagen expression

ChemicalCAS301836-41-9MW384.39FormulaC22H16N4O3
CAS number
301836-41-9
Molecular weight
384.39
Formula
C22H16N4O3
Solubility
≥ 19·2mg/mL in DMSO, ≥ 10·06 mg/mL in EtOH with ultrasonic
InChIKey
FHYUGAJXYORMHI-UHFFFAOYSA-N
Catalogue number
GC11545
Brand
GLPBIO
Computed properties PubChem CID 4521392 · XLogP 2.7 · TPSA 103 Ų · H-bond donors 2
XLogP
2.7
TPSA
103 Ų
H-bond donors
2
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
29

SMILES C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5

Computed descriptors from PubChem (CID 4521392), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.