GC11525
Pyridone 6
Also known as 4-tert-butyl-15-fluoro-3,5,10-triazatetracyclo[11.4.0.02,6.07,12]heptadeca-1(13),2(6),4,7(12),8,14,16-heptaen-11-one
Pyridone 6 inhibits Jak3 with K(I)=5 nM; Pyridone 6 also inhibits Jak family members Tyk2 and Jak2 with IC(50)=1 nM and Jak1 with IC(50)=15 nM
ChemicalCAS457081-03-7MW309.34FormulaC18H16FN3O
- CAS number
- 457081-03-7
- Molecular weight
- 309.34
- Formula
- C18H16FN3O
- Solubility
- ≥ 15·45 mg/mL in DMSO, ≥ 5·92 mg/mL in EtOH with ultrasonic and warming
- InChIKey
- VNDWQCSOSCCWIP-UHFFFAOYSA-N
- Catalogue number
- GC11525
- Brand
- GLPBIO
Computed properties PubChem CID 5494425 · XLogP 4 · TPSA 57.8 Ų · H-bond donors 2
- XLogP
- 4
- TPSA
- 57.8 Ų
- H-bond donors
- 2
- H-bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 23
SMILES CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
Computed descriptors from PubChem (CID 5494425), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il