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Chemical structure of Irinotecan

GC11473

Irinotecan

Also known as [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate

Irinotecan is a topoisomerase inhibitor used primarily for the treatment of colorectal cancer· Irinotecan binds to the topoisomerase I-DNA complex, preventing DNA strand reconnection and leading to DNA double-strand breaks and cell death

ChemicalCAS97682-44-5MW586.68FormulaC33H38N4O6
CAS number
97682-44-5
Molecular weight
586.68
Formula
C33H38N4O6
Solubility
>29·4mg/mL in DMSO
InChIKey
UWKQSNNFCGGAFS-XIFFEERXSA-N
Catalogue number
GC11473
Brand
GLPBIO
Computed properties PubChem CID 60838 · XLogP 3 · TPSA 113 Ų · H-bond donors 1
XLogP
3
TPSA
113 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
5
Heavy atoms
43

SMILES CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7

Computed descriptors from PubChem (CID 60838), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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