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Chemical structure of SAR405

GC11471

SAR405

Also known as (8S)-9-[(5-chloro-3-pyridinyl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-7,8-dihydro-6H-pyrimido[1,2-a]pyrimidin-4-one

SAR405 is a Vps34 inhibitor (IC50=1·2 nM),SAR405 inhibits autophagy caused by mTOR inhibition

ChemicalCAS1523406-39-4MW443.85FormulaC19H21ClF3N5O2
CAS number
1523406-39-4
Molecular weight
443.85
Formula
C19H21ClF3N5O2
Solubility
≥ 22·2mg/mL in DMSO
InChIKey
SPDQRCUBFSRAFI-DOMZBBRYSA-N
Catalogue number
GC11471
Brand
GLPBIO
Computed properties PubChem CID 72709209 · XLogP 2.2 · TPSA 61.3 Ų · H-bond donors 0
XLogP
2.2
TPSA
61.3 Ų
H-bond donors
0
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
30

SMILES C[C@@H]1COCCN1C2=CC(=O)N3CC[C@H](N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F

Computed descriptors from PubChem (CID 72709209), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.