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Chemical structure of Ki16425

GC11374

Ki16425

Also known as 3-[[4-[4-[1-(2-chlorophenyl)ethoxycarbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]methylsulfanyl]propanoic acid

Ki16425 is an antagonist of the lysophosphatidic acid receptors LPA1 and LPA3 and Ki values are 0·25 and 0·36μM respectly· Ki16425 reduces the LPA-induced activation of p42/p44 MAPK·Blocks LPA-induced dephosphorylation of Yes-associated protein (YAP) and WW domain-containing transcription regulator protein 1 (TAZ), inhibiting the Hippo signaling pathway

ChemicalCAS355025-24-0MW474.96FormulaC23H23ClN2O5S
CAS number
355025-24-0
Molecular weight
474.96
Formula
C23H23ClN2O5S
Solubility
≥ 23·75mg/mL in DMSO
InChIKey
LLIFMNUXGDHTRO-UHFFFAOYSA-N
Catalogue number
GC11374
Brand
GLPBIO
Computed properties PubChem CID 10367662 · XLogP 4.5 · TPSA 127 Ų · H-bond donors 2
XLogP
4.5
TPSA
127 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
10
Heavy atoms
32

SMILES CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2Cl)C3=CC=C(C=C3)CSCCC(=O)O

Computed descriptors from PubChem (CID 10367662), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Lead time
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Pricing
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Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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