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Chemical structure of Motesanib Diphosphate

GC11336

Motesanib Diphosphate

Also listed as Motesanib Diphosphate (AMG-706)

Motesanib Diphosphate (AMG-706) (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective for VEGFR than PDGFR and Ret

ChemicalCAS857876-30-3MW569.44FormulaC22H23N52H3PO4
CAS number
857876-30-3
Molecular weight
569.44
Formula
C22H23N52H3PO4
Solubility
≥ 28·45mg/mL in DMSO, ≥ 3·47 mg/mL in EtOH with ultrasonic
InChIKey
ONDPWWDPQDCQNJ-UHFFFAOYSA-N
Catalogue number
GC11336
Brand
GLPBIO
Computed properties PubChem CID 16097729 · TPSA 234 Ų · H-bond donors 9 · H-bond acceptors 13
TPSA
234 Ų
H-bond donors
9
H-bond acceptors
13
Rotatable bonds
5
Heavy atoms
38

SMILES CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C.OP(=O)(O)O.OP(=O)(O)O

Computed descriptors from PubChem (CID 16097729), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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